Efficacy of a novel artificial liver versatile plasma purification system in patients with acute-on-chronic liver failure

Table 2 Cox regression analysis of the effect of versatile plasma purification system treatment on prognosis of patients with liver failure

Variables	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
VPPS/non-VPPS
VPPS	Reference		Reference
Non-VPPS	3.676 (2.799, 4.827)	< 0.001	3.24 (2.152, 4.76)	< 0.001
Age	1.231 (1.03, 1.428)	0.003	1.142 (1.01, 1.23)	0.018
Sex (male)	1.225 (1.164, 2.18)	0.036	1.17 (0.886, 2.102)	0.120
Peritonitis	3.46 (1.75, 8.52)	0.012	2.825 (1.07, 6.382)	0.026
ALB	0.276 (0.128, 0.396)	< 0.001	0.67 (0.46, 0.942)	0.023
TBIL	1.987 (1.06, 3.963)	< 0.001	1.26 (1.01, 3.25)	0.021
INR	2.623 (1.05, 3.742)	< 0.001	1.97 (1.21, 2.908)	0.014

VPPS: Versatile plasma purification system; ALB: Albumin; TBIL: Total bilirubin; INR: International normalized ratio; HR: Hazard ratio.