Nonalcoholic fatty liver disease following laparoscopic duodenum-preserving pancreatic total head resection vs laparoscopic pancreaticoduodenectomy: A retrospective cohort study

Table 4 Postoperative laboratory and imaging variables of patients undergoing laparoscopic pancreaticoduodenectomy and laparoscopic duodenum-preserving total pancreatic head resection, n (%)

Variables	Overall (n = 59)	LPD group (n = 35)	LDPPHRt group (n = 24)	P value
Postoperative within 6-12 months
Weight (kg)	55.17 ± 8.53	55.81 ± 8.69	54.24 ± 8.37	0.492
AST (U/L)	23 [17, 32]	27 [20, 42]	21 [16, 27]	0.022
ALT (U/L)	23 [13, 46]	28 [12, 47]	22 [13, 40]	0.346
AST/ALT	1.1 [0.8, 1.5]	1.1 [0.9, 1.5]	1.2 [0.7, 1.4]	0.459
FIB-4 index	1.3 [0.8, 1.9]	1.4 [0.8, 2.2]	0.8 [0.7, 1.6]	0.020
Albumin (g/L)	40.5 ± 3.3	40.5 ± 6.0	41.2 ± 6.0	0.645
Total cholesterol (mmol/L)	3.7 [3.2, 4.3]	3.8 [3.4, 4.4]	3.5 [3.2, 4.1]	0.203
Random blood glucose(mmol/L)	5.6 [5.1, 6.5]	5.7 [5.2, 6.6]	5.6 [4.9, 6.7]	0.534
TBIL (μmol/L)	10.5 [8.0, 15.0]	11.0 [8.7, 15.0]	9.0 [6.8, 14.5]	0.316
NFS index	-2.2 [-3.5, -1.3]	-2.0 [-3.0, -1.0]	-2.8 [-3.9, -1.8]	0.050
ALP (U/L)	87 [70.0, 129.0]	95.0 [78.0, 192.0]	84.5 [58.5, 97.0]	0.035
de novo NAFLD	17 (28.8)	14 (40.0)	3 (12.5)	0.022
Liver-to-spleen CT attenuation differential (HU)	5.0 [-3.3, 11.5]	1.7 [-8.0, 9.0]	9.4 [4.1, 14.3]	0.018
Liver-to-spleen CT attenuation ratio	1.0 [1.0, 1.1]	1.0 [0.9, 1.1]	1.1 [1.0, 1.1]	0.030

ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; CT: Computed tomography; FIB-4: Fibrosis-4; GGT: Gamma-glutamyl transferase; HU: Hounsfield unit; LDPPHRt: Laparoscopic duodenum-preserving total pancreatic head resection; LPD: Laparoscopic Pancreaticoduodenectomy; NAFLD: Nonalcoholic fatty liver disease; TBIL: Total bilirubin; NFS: Nonalcoholic fatty liver disease fibrosis score.