Amoxicillin high-dose dual therapy for Helicobacter pylori primary eradication: Proton pump inhibitor and potassium-competitive acid blocker, which’s better?

Figure 1 Flow chart of patient recruitment. A: The study of 14-day esomeprazole and amoxicillin high-dose dual therapy and 14-day bismuth-containing quadruple therapy (14-day esomeprazole, amoxicillin, clarithromycin, and bismuth therapy); B: The study of 14-day vonoprazan and amoxicillin high-dose dual therapy and 14-day vonoprazan, amoxicillin, and clarithromycin therapy. ITT: Intention-to-treat; mITT: Modified intention-to-treat; PP: Per-protocol; UBT: Urea breath test; EA: Esomeprazole-amoxicillin; B-quadruple: Esomeprazole-amoxicillin-clarithromycin-bismuth; VA: Vonoprazan-amoxicillin; VAC: Vonoprazan-amoxicillin-clarithromycin.