Amoxicillin high-dose dual therapy for Helicobacter pylori primary eradication: Proton pump inhibitor and potassium-competitive acid blocker, which’s better?

doi:10.3748/wjg.v31.i13.100863

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Apr 7, 2025 (publication date) through Apr 15, 2025

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Apr 7, 2025; 31(13): 100863
Published online Apr 7, 2025. doi: 10.3748/wjg.v31.i13.100863

Table 7 Multivariate analysis of factors related to eradication rates

Variables	14d-EA group and 14d-B-quadruple group (n = 353)			14d-VA group and 14d-VAC group (n = 325)
Variables	OR	OR 95%CI	P value	OR	OR 95%CI	P value
History of antibiotics use in 2 years	7.242	[1.489, 35.214]	0.014^a	5.643	[1.548, 20.572]	0.009^a
Compliance	83.037	[3.805, 1812.024]	0.005^a	9.381	[2.064, 42.633]	0.004^a
Urban area	6.064	[1.938, 18.975]	0.002^a	3.906	[1.357, 11.248]	0.012^a

^aP < 0.05.

EA: Esomeprazole-amoxicillin; B-quadruple: Esomeprazole-amoxicillin-clarithromycin-bismuth; VA: Vonoprazan-amoxicillin; VAC: Vonoprazan-amoxicillin-clarithromycin.

Citation: Yang XE, Zhang SJ, Liu Y, Yao SY, Zhang SX, Liu XM, Liang LX, Wang F. Amoxicillin high-dose dual therapy for Helicobacter pylori primary eradication: Proton pump inhibitor and potassium-competitive acid blocker, which’s better? World J Gastroenterol 2025; 31(13): 100863
URL: https://www.wjgnet.com/1007-9327/full/v31/i13/100863.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i13.100863