Amoxicillin high-dose dual therapy for Helicobacter pylori primary eradication: Proton pump inhibitor and potassium-competitive acid blocker, which’s better?

Table 1 Baseline characteristics of patients, n (%)

Baseline factors	Total (n = 439)	14d-EA group (n = 221)	14d-B-quadruple group (n = 218)	P value1	Total (n = 367)	14d-VA group (n = 183)	14d-VAC group (n = 184)	P value2
Sex (male/female)	196/243	100/121	96/122	0.798	171/196	83/100	88/96	0.635
Age (years)	41.14 ± 12.07	41.05 ± 11.88	41.22 ± 12.29	0.879	43.04 ± 13.19	42.38 ± 13.60	43.69 ± 12.77	0.341
Fixed occupation (no/yes)	163/276 (62.87)	79/142 (64.25)	84/134 (61.47)	0.546	145/222 (60.49)	70/113 (61.75)	75/109 (59.24)	0.623
Ethnic group (Han/others)	420/19 (95.67)	211/10 (95.48)	209/9 (95.87)	0.838	349/18 (95.10)	175/8 (95.63)	174/10 (94.57)	0.637
BMI (kg/m²)	22.85 ± 2.74	22.94 ± 2.74	22.76 ± 2.75	0.493	22.77 ± 2.98	22.58 ± 2.88	22.97 ± 3.07	0.206
BSA (m²)	1.65 ± 0.16	1.65 ± 0.16	1.65 ± 0.16	0.777	1.63 ± 0.18	1.63 ± 0.18	1.63 ± 0.18	0.672
Native place (human/others)	378/61 (86.10)	193/28 (87.33)	185/33 (84.86)	0.455	315/52 (85.83)	159/24 (86.89)	156/28 (84.78)	0.564
Education status (primary/junior high school/high school/college/above university)	33/ 56/74/208/68	13/29/42/105/32	20/27/32/103/36	0.534	29/47/62/171/58	11/24/29/83/36	18/23/33/88/22	0.240
Place of residence (urban area/suburban area/rural area)	360/49/30	180/23/18	180/26/12	0.506	301/41/25	150/18/15	151/23/10	0.447
Smoking (no/yes)	329/110 (25.06)	161/60 (27.15)	168/50 (22.94)	0.308	282/85 (23.16)	136/47 (25.68)	146/38 (20.65)	0.253
Drinking (none/occasional/frequent)	301/115/23	153/57/11	148/58/12	0.944	252/96/19	126/46/11	126/50/8	0.727
Past medical history (no/yes)	371/68 (15.49)	188/33 (14.93)	183/35 (16.06)	0.745	308/59 (16.08)	154/29 (15.85)	154/30 (16.30)	0.905
Family infection of H. pylori (no/Yes/undetected)	172/138/129	86/71/64	86/67/65	0.950	144/115/108	71/59/53	73/56/55	0.932

¹P values were obtained from two-sided comparisons of difference between the 14d-EA group and the 14d-B-quadruple group.

²P values were obtained from two-sided comparisons of difference between the 14d-VA group and the 14d-VAC group.

BMI: Body mass index; BSA: Body surface area; EA: Esomeprazole-amoxicillin; B-quadruple: Esomeprazole-amoxicillin-clarithromycin-bismuth; VA: Vonoprazan-amoxicillin; VAC: Vonoprazan-amoxicillin-clarithromycin.