Suppressor of cytokine signaling 2 modulates regulatory T cell activity to suppress liver hepatocellular carcinoma growth and metastasis

Figure 6 Suppressor of cytokine signaling 2 inhibits regulatory T-cell activity. A-C: In vitro induction of naïve T cells into Th1 A:, Th17 (B), and Th17 (C) subsets, with flow cytometry used to detect markers and quantify differentiation efficiency; D and E: Flow cytometry detection of Ki67 expression to evaluate the effect of suppressor of cytokine signaling 2 (SOCS2) overexpression on regulatory T-cell (Treg) cell proliferation; F and G: Flow cytometry detection of LAP expression to assess the impact of SOCS2 on Treg cell activity. ^cP < 0.001; SOCS2: Suppressor of cytokine signaling 2; Treg: Regulatory T-cell; IFN: Interferon; IL: Interleukin.