Suppressor of cytokine signaling 2 modulates regulatory T cell activity to suppress liver hepatocellular carcinoma growth and metastasis

Figure 3 Key genes associated with liver hepatocellular carcinoma and their prognostic evaluation. A: Forest plot showing 34 significant genes identified by univariate COX regression; B: Partial likelihood deviance of least absolute shrinkage and selection operator (LASSO) coefficient distribution, with Lambda = 0.03; C: Identification of 29 candidate genes through LASSO analysis, with Lambda = 0.03; D: Kaplan-Meier curves comparing the prognosis differences between high-risk and low-risk groups based on the RSs from LASSO analysis; E: Receiver operating characteristic analysis at 1, 3, and 5 years based on the RSs from LASSO analysis; F: Nomogram predicting the 1-year, 3-year, and 5-year survival probabilities of breast cancer patients in a line chart format; G: Calibration plots of the line chart for predicting the overall survival at 1, 3, and 5 years (green: 1 year; blue: 3 years; red: 5 years); H: Decision curve analysis curve for the total survival rates at 1, 3, and 5 years (the x-axis represents the threshold probability, the y-axis represents the net benefit, where the net benefit is the relative benefit obtained by subtracting the weighted false positive rate from the true positive rate based on the threshold probability; "None" and "ALL" are two reference lines, and the closer other model curves are to these reference lines, the less practical value they have; a higher y-axis value under the same x-axis condition indicates a better model performance; if the y-axis values are consistently higher than other models over a large range of threshold values on the x-axis, it indicates superior model performance). Liver hepatocellular carcinoma, n = 367. SOCS2: Suppressor of cytokine signaling 2; Treg: Regulatory T-cell.