Peroral endoscopic myotomy for achalasia and patients with normal lower-esophageal-sphincter integrated relaxation pressure: A propensity-score-matched retrospective study

Table 4 Clinical characteristics and outcomes matched by propensity score, n (%)

	Normal LES-IRP group (n = 69)	Increased LES-IRP group (n = 69)	P value
Sex, male/female (n)	35/34	41/28	0.305
Age, median (Q1-Q3) (years)	45.0 (34.0-55.0)	44.0 (35.5-56.0)	0.797
BMI, median (Q1-Q3) (kg/m2)	21.5 (19.1-23.7)	20.9 (19.0-24.1)	0.764
Duration of symptoms, median (Q1-Q3) (months)	60.0 (24.0-174.0)	60.0 (24.0-120.0)	0.582
Previous treatment	19 (27.5)	18 (26.1)	0.848
ASA classification			0.573
I	6	8
II	62	59
III	1	2
Ling classification			0.145
Type Ling I	6 (8.7)	16 (23.2)
Type Ling IIa	21 (30.4)	18 (26.1)
Type Ling IIb	17 (24.7)	16 (23.2)
Type Ling IIc	21 (30.4)	18 (26.1)
Type Ling III	4 (5.8)	1 (1.4)
Pre-treatment HRM
LES basal pressure, median (Q1-Q3) (mmHg)	14.8 (12.0-20.3)	31.9 (22.5-40.4)	0.000
LES-IRP, median (Q1-Q3) (mmHg)	11.4 (9.3-12.5)	22.3 (19.0-28.4)	0.000
Follow-up period, median (Q1-Q3) (month)	25.0 (18.5-54.5)	42.0 (28.5-63.5)	0.002
Clinical success (Eckardt score ≤ 3)	61 (88.4)	62 (89.9)	0.784
Intraoperative adverse events	5 (7.1)	8 (11.5)	1.000
Bleeding	1 (1.4)	1 (1.4)
Mucosal injury	3 (4.3)	4 (5.8)
Gas-related adverse events	1 (1.4)	3 (4.3)
Pneumothorax	0 (0.0)	1 (1.4)
Pneumoperitoneum	1 (1.4)	2 (2.9)
Eckardt score, median (Q1-Q3)
Pre-treatment	7.0 (5.0-8.0)	7.0 (6.0-9.0)	0.021
Post-treatment	1.0 (0.0-2.0)	1.0 (1.0-2.0)	0.201
Pre-post change	5.0 (4.0-7.0)	6.0 (4.0-8.0)	0.086
GerdQ score, median (Q1-Q3)	6.0 (6.0-7.0)	6.0 (6.0-7.0)	0.917
GerdQ score ≥ 9	6 (8.7)	7 (10.1)	0.771

Data were expressed as median (Q1-Q3) or n (%). Continuous variables were compared by Mann-Whitney U test. Categorical variables were compared by χ² test or Fisher exact test. Q1: First quartile; Q3: Third quartile; BMI: Body mass index; LES: Lower esophageal sphincter; LES-IRP: Lower esophageal sphincter integrated relaxation pressure.