Antibiotic resistance of Helicobacter pylori and related risk factors in Hunan Province: A multicenter study

Table 3 Analysis of factors associated with antibiotic resistance of Helicobacter pylori, n (%)

Factor	Clarithromycin	Levofloxacin	Metronidazole	Amoxicillin	Furazolidone	Tetracycline
Age, years
18-40 (n = 115)	45 (39.1)	34 (29.6)	85 (73.9)	1 (0.9)	1 (0.9)	0 (0.0)
41-59 (n = 347)	172 (49.6)	131 (37.8)	270 (77.8)	8 (2.3)	6 (1.7)	4 (1.2)
60-80 (n = 104)	62 (59.6)	49 (47.1)	76 (73.1)	4 (3.8)	1 (1.0)	0 (0.0)
P value	0.010	< 0.001	0.500	0.339	1.000	0.473
Sex
Male (n = 276)	131 (47.5)	103 (37.3)	202 (73.2)	6 (2.2)	2 (0.7)	2 (0.7)
Female (n = 290)	148 (51.0)	111 (38.3)	229 (79.0)	7 (2.4)	6 (2.1)	2 (0.7)
P value	0.396	0.814	0.107	0.849	0.287	1.000
Treatment history
No (n = 434)	182 (41.9)	141 (32.5)	322 (74.2)	8 (1.8)	4 (0.9)	2 (0.5)
Yes (n = 132)	97 (73.5)	73 (55.3)	109 (82.6)	5 (3.8)	4 (3.0)	2 (1.5)
P value	< 0.001	< 0.001	0.048	0.194	0.090	0.233
Gastric disease
Ulcer (n = 194)	82 (42.3)	64 (33.0)	147 (75.8)	5 (2.6)	2 (1.0)	0 (0.0)
Atrophic gastritis (n = 65)	41 (63.1)	31 (47.7)	52 (80.0)	2 (1.5)	1 (1.5)	2 (3.1)
Non-atrophic gastritis (n = 283)	145 (51.2)	106 (37.5)	214 (75.6)	10 (2.1)	4 (1.4)	1 (0.4)
Others (n = 24)	12 (50.0)	14 (58.3)	19 (79.2)	1 (4.2)	1 (4.2)	1 (4.2)
P value	0.027	0.031	0.997	0.753	0.464	0.078
Regions
Northern Hunan (n = 350)	188 (53.7)	140 (40.0)	259 (74.0)	11 (3.1)	6 (1.7)	4 (1.1)
Central Hunan (n = 75)	39 (52.0)	36 (48.0)	71 (94.7)	0 (0.0)	1 (1.3)	0 (0.0)
Southern Hunan (n = 127)	45 (35.4)	34 (26.8)	87 (68.5)	2 (1.6)	1 (0.8)	0 (0.0)
Western Hunan (n = 14)	7 (50.0)	4 (28.6)	14 (100)	0 (0.0)	0 (0.0)	0 (0.0)
P value	0.005	0.011	< 0.001	0.430	0.897	0.787