Increased keratin 80 expression predicts poor prognosis and promotes oxaliplatin resistance in gastric cancer

Figure 4 Keratin 80 upregulation contributes to oxaliplatin resistance. A: The IC₅₀ values for oxaliplatin were determined in AGS and SGC7901 cell lines using cell viability assays; B: Immunofluorescence staining with phalloidin was performed to visualize alterations in microfilament structures in gastric cancer (GC) cells following oxaliplatin treatment; C: Flow cytometry was used to assess the effect of keratin 80 on apoptosis in GC cells after oxaliplatin treatment, by measuring the percentage of apoptotic cells in each group. Data are shown as the mean ± SD (n = 3). Data are shown as the mean ± SD (n = 3). ^aP < 0.05; ^bP < 0.05; ^cP < 0.001; KRT80: Keratin 80.