Increased keratin 80 expression predicts poor prognosis and promotes oxaliplatin resistance in gastric cancer

Figure 1 Keratin 80 expression is upregulated in gastric cancer and predicts an unfavorable prognosis. A-C: The mRNA expression level and protein expression of keratin 80 (KRT80) was quantified by quantitative real-time PCR and Western blot, the results show that KRT80 is upregulated in both gastric cancer (GC) cells and tumor tissues; D: Representative immunohistochemical staining images showing KRT80 expression in a GC tissue microarray; E: Statistical analysis of KRT80 expression in GC and adjacent normal tissues, where the final score represents the product of the staining area and intensity. High expression was classified as a final score of ≥ 5, while low expression was defined by a score of 0-4; F: Kaplan-Meier survival analysis comparing survival rates of GC patients with high and low KRT80 expression from our study; G: Kaplan-Meier survival curve of KRT80 expression data retrieved from the Kaplan-Meier Plotter database. Data are shown as the mean ± SD (n = 3). ^aP < 0.05; ^bP < 0.05; ^cP < 0.001; KRT80: Keratin 80; HR: Hazard ratio.