Characterization of hepatic pathology during azoxymethane-induced acute liver failure

Figure 5 Hepatic cell death is associated with azoxymethane toxicity. A: TUNEL staining images of livers from vehicle and azoxymethane (AOM)-treated mice at the pre, minor, major and coma time points; B: Percent area of TUNEL staining from vehicle and AOM-treated mice liver sections at the pre, minor, major and coma time points; C and D: Representative immunoblot and quantification of cleaved caspase 3 in liver homogenates from vehicle and AOM-treated liver sections at the pre, minor, major and coma time points. GAPDH was used as a protein loading control. n ≥ 3 for each group for all analyses. ^aP < 0.05 compared to vehicle-treated mice.