scRNA-seq of the intestine reveals the key role of mast cells in early gut dysfunction associated with acute pancreatitis

Figure 5 Enhanced antibacterial ability of intestinal cytotoxic T cells in acute pancreatitis. A: Representative enriched gene ontology terms for differentially expressed genes (DEGs) in cytotoxic T cells from the AP1 and normal groups based on scRNA-seq data; B: Representative enriched Kyoto Encyclopedia of Genes and Genomes pathways for DEGs in cytotoxic T cells from the AP2 and AP1 groups; C: Selected dysregulated genes, including Apoa1, Actg1, Coro1a, Gzma, Gzmb, and Reg3b, in cytotoxic T cells; D: UMAP plot showing 6 cytotoxic T-cell subclusters in the intestine; E: Expression of selected genes in cytotoxic T-cell subclusters, including Gzma, Gzmb, Ifng, Apoa1, Coro1a, Cd27, Cd8a, Cd69, Lag3, Cd244, Cd38, Itga4, Ccr9, Cxcr3, Cd3e, Cd3d, Il2, Mki67, Cdk1, Cdk4, and Cdk6; F: Percentage of cells in each cytotoxic T-cell subcluster. GO: Gene ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes.