To activate a G protein-coupled receptor permanently with cell surface photodynamic action in the gastrointestinal tract

doi:10.3748/wjg.v31.i12.102423

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World Journal of Gastroenterology

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2025; 31(12): 102423
Published online Mar 28, 2025. doi: 10.3748/wjg.v31.i12.102423

Table 2 Genetically encoded protein photosensitizers[89-91]

Photosensitiser	Number of amino acid residues	Chromophore	Maximal excitation wavelength (nm)	Maximal emission wavelength (nm)	Quantum yield of ¹O₂ generation	Fluorescence quantum yield
KillerRed	239	QYG	585	610	0.008	0.25
SuperNova	239	QYG	579	610	0.022	0.30
SuperNovaGreen	239	QWG	440	510	ND	0.23
KillerOrange	239	QWG	512	550	ND	0.42
TagRFP	237	MYG	555	584	0.004	0.48
miniSOG	106	FMN	448	500	0.03	0.45
AsLOV2	175	FMN	448	492	ND	ND
miniSOG2	106	FMN	430	503	ND	ND
Mr4511^C71S/G	16	FMN	45	495	0.17/0.1	ND
Pp2FbFP^L30M	148	FMN	449	495	0.09	0.25
DsFbFP	138	FMN	449	498	0.33	0.35
EcFbFP	135	FMN	448	496	0.07	0.44
CreiLOV	119	FMN	449	497	0.04	0.32
miniSOG^Q103L/V	106	FMN	440	487	0.25/0.39	0.43
SOPP2/3	106	FMN	440	487	0.51/0.61	0.41/0.39
phiSOG	218	FMN	449	498	0.02	0.36
phiSOG^Q103V	218	FMN	444	497	0.15	0.35
miniSOG^R57Q[89]	106	RF	450	530	0.05/0.07	ND
LovPSO[90]	105	FMN	450	507	0.68	0.27
LovPRO[91]	105	FMN	450	507	0.44	0.34

AsLOV2: Light, oxygen, voltage domain 2 of Aveva sativa; CreiLOV: Light, oxygen, voltage domain of Chlamydomonas reinhardtii; DsFbFP: Flavin-binding fluorescent protein from Dinoroseobacter shibae; EcFbFP: Flavin-binding fluorescent protein from Bacillus subtilis; FMN: Flavin mononucleotide; LovPRO: Light, oxygen, voltage photosensitizer for reactive oxygen species, derived from phototropin 2 of Oryza sativa japanicus; LovPSO: Light, oxygen, voltage photosensitizer for singlet oxygen; miniSOG: Mini singlet oxygen generator; Mr4511^C71S/G: Flavin-binding protein from Methylobacterium radiotolerans, with point mutations of Cys17Ser or Cys17Gly; MYG: Met-Trp-Gly; ND: Not determined; phiSOG: Mini singlet oxygen generator tethered dimer with one monomer having enhanced photostability; PpFbFP: Flavin-binding fluorescent protein from Pseudomonas putida; QWG: Gln-Trp-Gly; QYG: Gln-Tyr-Gly; RF: Riboflavin; SOPP: Singlet oxygen protein photosensitizer. Updated from Li and Cui[36]. Citation: Li Y, Cui ZJ. Photodynamic Activation of Cholecystokinin 1 Receptor with Different Genetically Encoded Protein Photosensitizers and from Varied Subcellular Sites. Biomolecules 2020; 10: 1423. Copyrights© The Authors 2020. Published by MDPI.

Citation: Cui ZJ. To activate a G protein-coupled receptor permanently with cell surface photodynamic action in the gastrointestinal tract. World J Gastroenterol 2025; 31(12): 102423
URL: https://www.wjgnet.com/1007-9327/full/v31/i12/102423.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i12.102423