To activate a G protein-coupled receptor permanently with cell surface photodynamic action in the gastrointestinal tract

doi:10.3748/wjg.v31.i12.102423

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Mar 28, 2025 (publication date) through Apr 3, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2025; 31(12): 102423
Published online Mar 28, 2025. doi: 10.3748/wjg.v31.i12.102423

Table 1 Comparison of the properties of novel types of G protein coupled receptors

Abbreviation	RASSL/DREADD	GPCR-ABSO
Activation	By synthetic ligands/designer drugs	By ¹O₂
Ligand dependent	Yes	No
Desensitization	Yes	One-off activation
Selectivity	Not activated by endogenous agonists	Double selectivity¹
Permanent activation	No	Yes
Apply to multiple GPCR?	Yes	Yes
Allosteric modulation?	No	Possible (positive/negative)

¹Photosensitizer localization/localized light irradiation.

¹O₂: Delta singlet oxygen; DREADD: Designer receptors exclusively activated by designer drugs; GPCR: G protein coupled receptor; GPCR-ABSO: G protein coupled receptor activated by singlet oxygen; RASSL: Receptors activated solely by synthetic ligands.

Citation: Cui ZJ. To activate a G protein-coupled receptor permanently with cell surface photodynamic action in the gastrointestinal tract. World J Gastroenterol 2025; 31(12): 102423
URL: https://www.wjgnet.com/1007-9327/full/v31/i12/102423.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i12.102423