NMDAR2B/PKA/CREB signaling pathway contributes to esophageal neuropathic pain in gastroesophageal reflux disease

doi:10.3748/wjg.v31.i11.98974

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 21, 2025; 31(11): 98974
Published online Mar 21, 2025. doi: 10.3748/wjg.v31.i11.98974

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Figure 4 Immunopositive product expression of N-methyl-D-aspartate pathway-related proteins in the distal esophageal mucosa of rats in each group (original magnification: × 200). A: Control; B: Model; C: Model + N-methyl-D-aspartate receptor (NMDAR) agonist; D: Model + NMDAR antagonist; E: Model + protein kinase A (PKA) antagonist; F: Model + NMDAR antagonist + PKA agonist. SP: Substance P; CGRP: Calcitonin gene-related peptide.

Citation: Wang Y, Li GW, Zhu SL, Xu TT, Qin YW, Cheng CQ, Zheng QW, He C, Zhou BD, Fang SQ. NMDAR2B/PKA/CREB signaling pathway contributes to esophageal neuropathic pain in gastroesophageal reflux disease. World J Gastroenterol 2025; 31(11): 98974
URL: https://www.wjgnet.com/1007-9327/full/v31/i11/98974.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i11.98974