NMDAR2B/PKA/CREB signaling pathway contributes to esophageal neuropathic pain in gastroesophageal reflux disease

doi:10.3748/wjg.v31.i11.98974

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 21, 2025; 31(11): 98974
Published online Mar 21, 2025. doi: 10.3748/wjg.v31.i11.98974

Table 3 Behavioral scores for esophageal acid infusion and balloon distension

Groups	Balloon distension	Acid infusion
Control	1.00 (1.00, 2.00)	2.00 ± 0.89
Model	3.00 ± 0.89^a	3.00 ± 0.89^a
Model + NR agonist	4.17 ± 0.75^b	4.17 ± 0.75^b
Model + NR antagonist	1.83 ± 0.75^b	2.00 ± 0.63^b
Model + PKA antagonist	1.83 ± 0.75^b	2.00 ± 0.89^b
Model + NR antagonist + PKA agonist	3.50 (2.75, 4.00)^c	3.50 (2.00, 4.00)^c

^aP < 0.05 vs control groups.

^bP < 0.05 vs model group.

^cP < 0.05 vs model + N-methyl-D-aspartate receptor antagonist group.

NR: N-methyl-D-aspartate receptor; PKA: Protein kinase A.

Citation: Wang Y, Li GW, Zhu SL, Xu TT, Qin YW, Cheng CQ, Zheng QW, He C, Zhou BD, Fang SQ. NMDAR2B/PKA/CREB signaling pathway contributes to esophageal neuropathic pain in gastroesophageal reflux disease. World J Gastroenterol 2025; 31(11): 98974
URL: https://www.wjgnet.com/1007-9327/full/v31/i11/98974.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i11.98974