NMDAR2B/PKA/CREB signaling pathway contributes to esophageal neuropathic pain in gastroesophageal reflux disease

doi:10.3748/wjg.v31.i11.98974

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 21, 2025; 31(11): 98974
Published online Mar 21, 2025. doi: 10.3748/wjg.v31.i11.98974

Table 2 Serum brain-derived neurotrophic factor concentration

Groups	BDNF (pg/mL)
Control	179.19 ± 13.42
Model	498.74 ± 69.92^a
Model + NR agonist	774.58 ± 113.18^c
Model + NR antagonist	322.79 ± 44.83^b
Model + PKA antagonist	265.63 ± 35.42^c
Model + NR antagonist + PKA agonist	384.03 ± 68.42

^aP < 0.001 vs control group.

^bP < 0.01 vs model group.

^cP < 0.001 vs model group.

NR: N-methyl-D-aspartate receptor; PKA: Protein kinase A; BDNF: Brain-derived neurotrophic factor.

Citation: Wang Y, Li GW, Zhu SL, Xu TT, Qin YW, Cheng CQ, Zheng QW, He C, Zhou BD, Fang SQ. NMDAR2B/PKA/CREB signaling pathway contributes to esophageal neuropathic pain in gastroesophageal reflux disease. World J Gastroenterol 2025; 31(11): 98974
URL: https://www.wjgnet.com/1007-9327/full/v31/i11/98974.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i11.98974