NMDAR2B/PKA/CREB signaling pathway contributes to esophageal neuropathic pain in gastroesophageal reflux disease

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Mar 21, 2025 (publication date) through Mar 31, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 21, 2025; 31(11): 98974
Published online Mar 21, 2025. doi: 10.3748/wjg.v31.i11.98974

Table 1 mRNA primer sequences

mRNA	Primers	Product length (bp)
NMDAR2B	Primer F 5’ AGCTCAGCGACCTGTATG 3’	204
	Primer R 5’ ACTCCCTCCTCGATTTGG 3’
PKA	Primer F 5' TCCTTTGGGCGAGTGATG 3'	283
	Primer R 5' CGTAGAAACGGGCGTGGG 3'
CREB	Primer F 5' CAGGGAGGAGCAATACAG 3'	148
	Primer R 5' GCACTAGAATCTGCTGTCC 3'
BDNF	Primer F 5' TGGATGAGGACCAGAAGG 3'	115
	Primer R 5' AGAAAGAGCAGAGGAGGC 3'
GAPDH	Primer F 5' GGAGTCTACTGGCGTCTTCAC 3'	237
	Primer R 5' ATGAGCCCTTCCACGATGC 3'

NMDAR: N-methyl-D-aspartate receptor; PKA: Protein kinase A; CREB: cAMP-response element binding protein; BDNF: Brain-derived neurotrophic factor.

Citation: Wang Y, Li GW, Zhu SL, Xu TT, Qin YW, Cheng CQ, Zheng QW, He C, Zhou BD, Fang SQ. NMDAR2B/PKA/CREB signaling pathway contributes to esophageal neuropathic pain in gastroesophageal reflux disease. World J Gastroenterol 2025; 31(11): 98974
URL: https://www.wjgnet.com/1007-9327/full/v31/i11/98974.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i11.98974