Trichostatin A augments cell migration and epithelial-mesenchymal transition in esophageal squamous cell carcinoma through BRD4/c-Myc endoplasmic reticulum-stress pathway

doi:10.3748/wjg.v31.i11.103449

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 21, 2025; 31(11): 103449
Published online Mar 21, 2025. doi: 10.3748/wjg.v31.i11.103449

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Figure 7 A proposed model illustrating the mechanism by which trichostatin A promotes esophageal squamous cell carcinoma cell epithelial-mesenchymal transition and migration. ac: Acetylation; TSA: Trichostatin A; HAT: Histone lysine acetyltransferase; HDAC: Histone deacetylases; ER: Endoplasmic reticulum; EMT: Epithelial-mesenchymal transition; c-Myc: Cellular myelocytomatosis oncogene.

Citation: Chen YM, Yang WQ, Fan YY, Chen Z, Liu YZ, Zhao BS. Trichostatin A augments cell migration and epithelial-mesenchymal transition in esophageal squamous cell carcinoma through BRD4/c-Myc endoplasmic reticulum-stress pathway. World J Gastroenterol 2025; 31(11): 103449
URL: https://www.wjgnet.com/1007-9327/full/v31/i11/103449.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i11.103449