Inhibition of the SERPINB5/HSP90AA1 axis restrains the proliferation and invasion of rectal cancer

Figure 6 Serpin family B member 5 knockdown retarded rectal cancer tumor growth in xenograft mice. A: Tumors in the short-hairpin RNA targeting NC and short-hairpin RNA targeting serpin family B member 5 groups; B: Tumor volume was tested every 7 days following implantation; C: Tumor weight was assessed on day 28 after euthanasia; D and E: Serpin family B member 5 and heat shock protein 90 alpha class A member 1 protein levels in tumor tissues were examined through western blot analysis; F and G: Ki67 protein levels in tumor tissues were tested by using immunohistochemistry staining. Data are presented as mean ± SEM. ^aP < 0.01. SERPINB5: Serpin family B member 5; sh: short-hairpin RNA; HSP90AA1: Heat shock protein 90 alpha class A member 1; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase.