Inhibition of the SERPINB5/HSP90AA1 axis restrains the proliferation and invasion of rectal cancer

Figure 1 Serpin family B member 5 was prominently upregulated in rectal cancer. A: Gene Expression Profiling Interactive Analysis database was used to illustrate the relative serpin family B member 5 (SERPINB5) levels in rectal cancer tissues (left red) and normal tissues (right gray), ^aP < 0.01; B and C: Western blot analysis was conducted to assess SERPINB5 protein level in rectal cancer tissues and matched adjacent tissues (n = 27); D and E: SERPINB5 expression in the human normal colonic mucosa cell line FHC and rectal cancer cell lines (HR8348, SW480, SW837, and SW1463) was determined through western blot analysis. Data are presented as mean ± SEM. ^aP < 0.01. SERPINB5: Serpin family B member 5; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase.