NAD+/SIRT1 pathway regulates glycolysis to promote oxaliplatin resistance in colorectal cancer

Figure 7 Integrated analysis expression, prognostic value and associated molecular pathways of SIRT1 in colorectal cancer. A: Relationships between SIRT1 mRNA levels and individual cancer stages of colorectal cancer (CRC). ^dP < 0.0001; B: Relationships between SIRT1 mRNA levels and overall survival of CRC patients undergoing adjuvant chemotherapy were conducted using Kaplan-Meier analysis; C: Volcano plot of differentially expressed genes in CRC patients with high and low SIRT1 mRNA expression. Yellow dots represent upregulated genes; blue dots represent downregulated genes; gray dots represent non-significant genes; D: Gene Ontology functional enrichment analysis of differentially expressed genes; E: Gene Set Enrichment analysis in the low SIRT1 mRNA expression group. NES: Normalized enrichment scores.