Mitochondrial mt12361A>G increased risk of metabolic dysfunction-associated steatotic liver disease among non-diabetes

Table 3 Multivariate logistic regression analysis for the association between mt12361A>G and metabolic dysfunction-associated steatotic liver disease in the overall dataset, mean ± SD/n (%)

	Univariate			Multivariate
	MASLD	Control	P value	OR	95%CI	P value
n (%)	577 (44.0)	733 (56.0)
Age (years)	49.7 ± 12.1	47.7 ± 13.9	0.005	1.02	1.01-1.03	0.001
Sex (male)	340 (59.0)	277 (37.9)	3.5 × 10-14	1.54	1.19-1.99	9.3 × 10-4
Cholesterol (mg/dL)	200.4 ± 38.5	193.8 ± 38.4	0.002	0.99	0.99-1.00	4.9 × 10-4
LDL (mg/dL)	133.7 ± 36.1	120.2 ± 34.0	1.0 × 10-11	1.02	1.01-1.02	2.3 × 10-8
AST ULN ratio	0.61 ± 0.28	0.55 ± 0.29	2.7 × 10-4	0.15	0.06-0.40	1.4 × 10-4
ALT ULN ratio	0.70 ± 0.46	0.49 ± 0.35	1.1 × 10-17	11.43	5.88-22.22	6.7 × 10-13
mt12361A>G	26 (4.7)	13 (1.8)	0.003	2.54	1.19-5.43	0.016

OR: Odds ratio; CI: Confidence interval; MASLD: Metabolic dysfunction-associated steatotic liver disease; LDL: Low density lipoprotein cholesterol; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ULN: Upper limit of normal.