Mitochondrial mt12361A>G increased risk of metabolic dysfunction-associated steatotic liver disease among non-diabetes

Table 2 The association between mt12361 and steatotic liver disease

CMRF	Screening					Validation					All
	mt12361		χ2		Trend test	mt12361		χ2		Trend test	mt12361		χ2		Trend test
	A (%)	G (%)	P value	OR (95%CI)	P value	A (%)	G (%)	P value	OR (95%CI)	P value	A (%)	G (%)	P value	OR (95%CI)	P value
4-5	35 (85.4)	6 (14.6)	0.001	13.37 (2.59-69.05)	1.5 × 10-4	102 (97.1)	3 (2.9)	0.445	1.60 (0.44-5.76)	0.165	137 (93.8)	9 (6.2)	0.001	3.79 (1.61-8.93)	1.7 × 10-4
2-3	57 (89.1)	7 (10.9)	0.003	9.58 (1.93-47.47)		212 (95.9)	9 (4.1)	0.055	2.31 (0.96-5.55)		269 (94.4)	16 (5.6)	4.6 × 10-4	3.43 (1.65-7.13)
0-1	156 (98.7)	2 (1.3)	Ref.	Ref.		652 (98.2)	12 (1.8)	Ref.	Ref.		808 (98.3)	14 (1.7)	Ref.	Ref.
3-5	62 (84.9)	11 (15.1)	3.0 × 10-4	11.36 (2.44-52.80)	1.3 × 10-4	198 (97.5)	5 (2.5)	0.637	1.29 (0.44-3.77)	0.441	260 (94.2)	16 (5.8)	0.001	3.27 (1.55-6.89)	0.001
1-2	58 (96.7)	2 (3.3)	0.592	2.21 (0.30-16.05)		205 (96.2)	8 (3.8)	0.135	2.00 (0.79-5.04)		263 (96.3)	10 (3.7)	0.093	2.02 (0.88-4.67)
0	128 (98.5)	2 (1.5)	Ref.	Ref.		563 (98.1)	11 (1.9)	Ref.	Ref.		691 (98.2)	13 (1.8)	Ref.	Ref.
3-5	62 (84.9)	11 (15.1)	2.1 × 10-4	8.25 (2.54-26.85)	5.1 × 10-5	198 (97.5)	5 (2.5)	0.968	1.02 (0.38-2.77)	0.968	260 (94.2)	16 (5.8)	3.6 × 10-3	2.55 (1.33-4.90)	0.004
0-2	186 (97.9)	4 (2.1)	Ref.	Ref.		768 (97.6)	19 (2.4)	Ref.	Ref.		954 (97.6)	23 (2.4)	Ref.	Ref.

CMRF: Cardiometabolic risk factors; OR: Odds ratio; CI: Confidence interval.