SEL1L-mediated endoplasmic reticulum associated degradation inhibition suppresses proliferation and migration in Huh7 hepatocellular carcinoma cells

Figure 4 SEL1L knockout affected the tumor growth in vivo. A: Subcutaneous xenografts dissected from mice at the endpoint; B: Subcutaneous tumor growth curves in nude mice (n = 6); C: Subcutaneous xenograft weights from mice at the endpoint; D: The mRNA expression of heavy-chain binding protein (BiP) and inositol-requiring enzyme (IRE)-1α was detected by quantitative real-time polymerase chain reaction. Each point represents a single sample; E: The protein expression of BiP and IRE-1α in the SEL1L knockout group was compared with the scramble group. ^aP < 0.05. ^bP < 0.01. ^cP < 0.001. ^dP < 0.0001. GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; BiP: Heavy-chain binding protein; IRE-1α: Inositol-requiring enzyme-1α; KO: Knockout.