Lactococcus garvieae aggravates cholestatic liver disease by increasing intestinal permeability and enhancing bile acid reabsorption

Figure 6 Bile acids transportation is altered by Lactococcus garvieae. A: Serum TBA values from each group are presented; B: Apical sodium-dependent bile acid transporter mRNA levels in the intestine of each group; C and D: OATP, NTCP, BSEP, MDR1, cytochrome P450 family 7 subfamily A member 1, CYP8B1 and cytochrome P450 family 27 subfamily A member 1 mRNA levels in the livers of each group; E: Liver TC values from each group are presented. All values are expressed as the mean ± SD; ^aP < 0.05 vs phosphate-buffered saline (PBS) group; ^bP < 0.01 vs PBS group; ^cP < 0.05 vs 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) + PBS group; ^dP < 0.01 vs DDC + PBS group. PBS: Phosphate-buffered saline; L. garv: Lactococcus garvieae; DDC: 3,5-diethoxycarbonyl-1,4-dihydrocollidine; ASBT: Apical sodium-dependent bile acid transporter; GAPDH: Glyceraldehyde 3-phosphate dehydrogenase; CYP27A1: Cytochrome P450 family 27 subfamily A member 1; CYP7A1: Cytochrome P450 family 7 subfamily A member 1.