Platelet activation relieves liver portal hypertension via the lymphatic system though the classical vascular endothelial growth factor receptor 3 signaling pathway

Figure 1 Trends in the number of rat lymphatic vessels at 2 weeks and 4 weeks after bile duct ligation. A: Representative immunohistochemistry images of Masson’s trichrome, lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), vascular endothelial growth factor C (VEGF-C) and VEGF receptor 3 (VEGFR-3) staining in the livers of the different groups; B: Quantitative analysis of Masson’s trichrome; C: Quantitative analysis of LYVE-1; D: Quantitative analysis of VEGF-C; E: Quantitative analysis of VEGFR-3 staining; F: Luminal area of lymphatic vessels were also measured; G: The number of lymphatic vessels was also measured. The data represent the mean ± SD. ^aP < 0.05. ^bP < 0.01. ^cP < 0.001. BDL: Bile duct ligation; W: Week.