Real-world evidence on the efficacy and safety of vonoprazan-amoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

Table 1 Demographic and clinical data of all patients, n (%)

Characteristics	First-line treatment, n = 250	Rescue treatment, n = 130	P value
Age in years	65.3 ± 4.4	65.1 ± 3.6	0.6000
Range	60-82	60-76
Sex as M/F	106/144	60/70	0.5500
Body weight in kg	65.5 ± 11.3	65.8 ± 10.8	0.8000
BMI in kg/m2	24.0 ± 3.4	23.7 ± 2.9	0.3700
Cigarette smoking	31 (12.4)	15 (11.5)	0.9300
Alcohol drinking	35 (14.0)	27 (20.8)	0.1200
Family history of gastric cancer	15 (6.0)	15 (11.5)	0.0900
Endoscopy diagnosis
Gastritis	193 (77.2)	97 (77.2)	0.6600
CSG	108 (43.2)	32 (24.6)	0.0006c
CAG	85 (34.0)	65 (50.0)	0.0035b
Peptic ulcer	51 (20.4)	27 (20.8)	1.0000
Gastric ulcer	14 (5.6)	11 (4.4)	0.4000
Duodenal ulcer	27 (10.8)	16 (6.4)	0.7900
Complex (gastric and duodenal) ulcer	10 (4.0)	0 (0.0)	0.0180a
Gastric cancer	1 (0.4)	1 (0.8)	1.0000
MALToma	3 (1.2)	0 (0.0)	0.5500
Gastric hyperplastic polyp	2 (0.8)	5 (3.8)	0.0490a
Combined diseases	1.8 ± 1.4	1.8 ± 1.4	0.9020
0	53 (21.2)	26 (20.0)	0.8900
1	61 (24.4)	34 (26.1)	0.8000
2	64 (25.6)	35 (26.9)	0.8800
≥ 3	72 (28.8)	35 (16.9)	0.7900
Combined medicine	1.3 ± 1.6	1.5 ± 1.7	0.3400
0	99 (39.6)	45 (34.6)	0.4000
1	59 (23.6)	36 (27.7)	0.4500
2	40 (16.0)	17 (13.1)	0.5400
≥ 3	52 (20.8)	32 (24.6)	0.4700
Comorbidity
Hypertension	89 (35.6)	49 (37.7)	0.7700
Diabetes mellitus	45 (18.0)	20 (15.4)	0.6200
Hyperlipidemia	88 (35.2)	33 (25.4)	0.0700
Heart disease	32 (12.8)	15 (11.5)	0.8500
Lung disease	10 (4.0)	5 (3.8)	1.0000
Liver disease	28 (11.2)	12 (9.2)	0.6800
Renal disease	13 (5.2)	7 (5.4)	1.0000
Cerebrovascular disease	10 (4.0)	7 (5.4)	0.6000
Autoimmune disease	24 (9.6)	9 (6.9)	0.4500
Hypersensitivity disease	4 (1.6)	4 (3.1)	0.4500
Other malignant tumor	25 (10.0)	19 (14.6)	0.2400
Adherence	247 (98.8)	128 (98.5)	1.0000
Adverse events	23 (9.2); 95%CI: 6.2%-13.4%	13 (10.0); 95%CI: 4.8%-15.2%	1.0000
Eradication rate	95.6% (239/250); 95%CI: 93.0%-98.1%	89.2% (116/130); 95%CI: 83.9%-94.6%	0.0300a

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

Data are mean ± SD unless otherwise indicated. Cigarette smoking was defined by consumption of > 5 cigarettes a day or > 1 cigarette pack/week consumed in the past 6 months. A family history of gastric cancer was defined as a gastric cancer diagnosis in a first-degree relative (such as a parent, sibling, or child). Alcohol drinking was defined by > 50 g of alcohol/day consumed in the past 6 months. Compliance was defined by > 80% of tablets taken as instructed. BMI: Body mass index; CSG: Chronic superficial gastritis; CAG: Chronic astrophic gastritis; F: Female; M: Male; MALToma: Mucosa-associated lymphoid tissue lymphoma.