Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

doi:10.3748/wjg.v31.i1.101198

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 7, 2025; 31(1): 101198
Published online Jan 7, 2025. doi: 10.3748/wjg.v31.i1.101198

Table 2 Correlation between the expression of ASH1L and clinical blood examinations

Variable	High expression (n = 44)	Low expression (n = 67)	P value
ALT (U/L)	36.30 (24.40-56.35)	34.50 (20.60-47.90)	0.228
AST (U/L)	60.85 (42.20-104.13)	41.20 (27.30-64.20)	0.003
TB (μmol/L)	36.49 (17.53-75.96)	21.19 (13.70-37.71)	0.021
Scr (μmol/L)	65.05 (58.03-80.00)	66.00 (53.00-77.00)	0.424
ALB (g/L), mean ± SD	34.94 ± 5.98	35.20 ± 6.02	0.878
AFP (ng/mL)	215.90 (10.45-1705.50)	76.68 (6.34-1210.00)	0.187
WBC (× 10⁹/L)	4.23 (2.80-5.77)	4.51 (2.98-6.14)	0.387
HGB (g/L), mean ± SD	120.84 ± 24.98	125.09 ± 22.44	0.458
PLT (× 10⁹/L)	108.00 (55.25-145.75)	106.0 (64.00-163.00)	0.623
INR	1.19 (1.06-1.44)	1.21 (1.09-1.36)	0.594
PT (second)	12.95 (11.53-14.98)	13.60 (12.20-15.30)	0.197

TB: Total bilirubin; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALB: Albumin; WBC: White blood cell; HGB: Hemoglobin; PLT: Platelets; INR: International normalized ratio; PT: Prothrombin Time; Scr: Serum creatinine; AFP: Alpha-fetoprotein.

Citation: Yu XH, Xie Y, Yu J, Zhang KN, Guo ZB, Wang D, Li ZX, Zhang WQ, Tan YY, Zhang L, Jiang WT. Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression. World J Gastroenterol 2025; 31(1): 101198
URL: https://www.wjgnet.com/1007-9327/full/v31/i1/101198.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i1.101198