Staging liver fibrosis with various diffusion-weighted magnetic resonance imaging models

Table 3 Spearman correlation coefficients of diffusion-weighted imaging -derived parameters with the liver fibrosis stages

		Mono-ADC	IVIM-D	IVIM-D*	IVIM-f	DKI-MD	DKI-MK	SEM-DDC	SEM-α	FROC-D	FROC-β	FROC-μ	CTRW-D	CTRW-α	CTRW-β
S	r value	-0.362b	-0.251a	-0.154	-0.138	-0.297b	0.000	-0.263a	0.129	-0.350b	0.149	-0.321b	-0.356b	-0.297b	0.199
	P value	0.001	0.029	0.184	0.233	0.009	0.999	0.022	0.268	0.002	0.199	0.005	0.002	0.009	0.085

^aP ≤ 0.05.

^bP ≤ 0.01.

ADC: Apparent diffusion coefficient; IVIM-D: Intravoxel incoherent motion model-derived true diffusion coefficient; IVIM-D^*: Intravoxel incoherent motion model-derived pseudo-diffusion coefficient; IVIM-f: Intravoxel incoherent motion model-derived perfusion fraction; DKI-MD: Diffusion kurtosis imaging-derived apparent diffusivity; DKI-MK: Diffusion kurtosis imaging-derived excess kurtosis; SEM-DDC: Stretched exponential model-derived distributed diffusion coefficient; SEM-α: Stretched exponential model-derived intravoxel heterogeneity index; FROC-D: Fractional order calculus model-derived diffusion coefficient; FROC-β: Fractional order calculus model-derived fractional order parameter; FROC-μ: Fractional order calculus model-derived microstructural quantity; CTRW-D: Continuous-time random-walk model-derived anomalous diffusion coefficient; CTRW-α: Continuous-time random-walk model-derived temporal diffusion heterogeneity index; CTRW-β: Continuous-time random-walk model-derived spatial diffusion heterogeneity index; S: Liver fibrosis stages.