Guidelines
Copyright ©The Author(s) 2024.
World J Gastroenterol. Mar 7, 2024; 30(9): 1018-1042
Published online Mar 7, 2024. doi: 10.3748/wjg.v30.i9.1018
Table 4 Clinical trials of adjuvant treatment in hilar cholangiocarcinoma
Study
Design
Sample size
Treatment
Control
Key findings
JCOG1202, ASCOTPhase 3Total: 440; CCA: 180S-11Observation3-yr OS: 77.1% vs 67.6% (95%CI: 61.0%-73.3%); 3-yr RFS: 62.4% vs 50.9% (95%CI: 44.1%-57.2%)
BILCAPPhase 3Total: 447; CCA: 284Capecitabine, duration: 6 monthsObservationOS (month): 51.1 vs 36.4 (95%CI: 34.6%-59.1%); RFS (month): 24.4 vs 17.5 (95%CI: 18.6%-35.9%)
SWOG S0809Phase 2Total: 79; CCA: 53gemcitabine and capecitabine followed by CRRTNoneMedian OS: 35 months (R0, 34 months, R1, 35 months)

  • Citation: Dar FS, Abbas Z, Ahmed I, Atique M, Aujla UI, Azeemuddin M, Aziz Z, Bhatti ABH, Bangash TA, Butt AS, Butt OT, Dogar AW, Farooqi JI, Hanif F, Haider J, Haider S, Hassan SM, Jabbar AA, Khan AN, Khan MS, Khan MY, Latif A, Luck NH, Malik AK, Rashid K, Rashid S, Salih M, Saeed A, Salamat A, Tayyab GUN, Yusuf A, Zia HH, Naveed A. National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma. World J Gastroenterol 2024; 30(9): 1018-1042
  • URL: https://www.wjgnet.com/1007-9327/full/v30/i9/1018.htm
  • DOI: https://dx.doi.org/10.3748/wjg.v30.i9.1018