Mitochondrial dysfunction affects hepatic immune and metabolic remodeling in patients with hepatitis B virus-related acute-on-chronic liver failure

Figure 4 Metabolic profiles of the liver of patients with acute-on-chronic liver failure. A: Orthogonal partial least squares-discriminant analysis scatter plot; B: Permutation tests; C: Hierarchical clustergram of organic acid metabolites; D: Volcano plot comparing organic acid metabolites between patients with acute-on-chronic liver failure (n = 17) and healthy donors (n = 12); E: Quantitative analysis of differentially expressed organic acid metabolites; F: Kyoto Encylopedia of Genes and Genomes pathway enrichment analysis. Data with normal distribution were compared using unpaired student’s t-test, and the Mann-Whitney test was used for non-normal data. ACLF: Acute-on-chronic liver failure; HD: Healthy donor.