Retrospective Study
Copyright ©The Author(s) 2024.
World J Gastroenterol. Feb 28, 2024; 30(8): 863-880
Published online Feb 28, 2024. doi: 10.3748/wjg.v30.i8.863
Table 3 Results of the univariate and multivariate analyses to identify parameters predictive of progression-free survival and overall survival
Parameters
OS
PFS
Univariate analysis
Multivariate analysis
Univariate analysis
Multivariate analysis
Hazard ratio (95%CI)
P value
Hazard ratio (95%CI)
P value
Hazard ratio (95%CI)
P value
Hazard ratio (95%CI)
P value
ALT (U/L)1.191 (0.680-2.088)0.541 1.312 (0.748-2.301)0.343
AST (U/L)3.316 (0.457-24.065)0.236 4.063 (0.560-29.469)0.165
γ-GGT (U/L)0.914 (0.522-1.601)0.753 0.907 (0.511-1.610)0.739
ALP (U/L)1.673 (0.933-2.998)0.084 1.962 (1.096-3.513)0.0231.540 (0.722-3.282)0.264
TBIL (µmol/L)1.578 (0.861-2.893)0.140 2.108 (1.155-3.848)0.015 3.752 (1.104-12.750)0.034
DBIL (µmol/L)1.245 (0.705-2.197)0.450 1.337 (0.763-2.343)0.310
IDBIL (µmol/L)1.383 (0.785-2.434)0.261 1.870 (1.066-3.281)0.0290.847 (0.276-2.603)0.772
TP (g/L)0.389 (0.165-0.917)0.031 0.310 (0.126-0.765)0.011 0.502 (0.214-1.179)0.114
ALB (g/L)0.985 (0.542-1.791)0.961 1.212 (0.667-2.201)0.528
GLOB (g/L)0.380 (0.118-1.223)0.105 0.345 (0.107-1.114)0.075
PALB (g/L)0.518 (0.293-0.915)0.024 0.757 (0.414-1.384)0.366 0.524 (0.299-0.919)0.0240.560 (0.288-1.088)0.087
Urea (mmol/L)0.693 (0.362-1.328)0.269 0.711 (0.369-1.368)0.307
CREA (µmol/L)0.882 (0.486-1.600)0.679 1.007 (0.557-1.822)0.981
UA (µmol/L)0.571 (0.256-1.275)0.172 0.641 (0.284-1.446)0.284
LDH (U/L)1.094 (0.556-2.152)0.794 1.056 (0.543-2.051)0.873
WBC (109/L)1.500 (0.835-2.696)0.175 1.450 (0.809-2.598)0.212
NEU (109/L)1.352 (0.728-2.512)0.339 1.334 (0.719-2.475)0.360
Lym (109/L)0.581 (0.323-1.043)0.069 0.555 (0.308-0.998)0.0490.692 (0.345-1.391)0.301
Mono (109/L)0.727 (0.418-1.262)0.257 0.730 (0.421-1.267)0.264
Eosi (109/L)3.205 (1.520-6.758)0.002 2.398 (1.116-5.153)0.025 2.856 (1.374-5.936)0.0053.022 (1.341-6.809)0.008
Baso (109/L)1.151 (0.656-2.019)0.625 1.408 (0.797-2.489)0.239
Hb (g/L)1.062 (0.604-1.866)0.835 1.010 (0.576-1.772)0.973
RBC (1012/L)0.951 (0.542-1.667)0.860 0.946 (0.538-1.666)0.849
Plt (109/L)0.578 (0.308-1.085)0.088 0.590 (0.314-1.110)0.102
Fbg (g/L)0.044 (0.000-12.949)0.282 0.44 (0.000-7.917)0.238
DDi (mg/L)1.906 (0.978-3.715)0.058 1.883 (0.978-3.627)0.058
AFP ng/mL0.830 (0.473-1.454)0.514 0.871 (0.496-1.529)0.631
CEA ng/mL1.507 (0.796-2.855)0.208 1.175 (0.622-2.219)0.620
CA199 U/L1.605 (0.927-2.780)0.091 1.756 (1.015-3.037)0.0441.395 (0.719-2.706)0.325
CA724 U/L2.051 (1.176-3.578)0.011 2.459 (1.334-4.534)0.004 1.846 (1.055-3.228)0.032 1.951 (1.056-3.606)0.033
CA125 II U/L2.408 (1.294-4.482)0.006 2.763 (1.302-5.862)0.008 2.735 (1.445-5.179)0.0022.419 (1.094-5.348)0.029
BMI (kg/m2)0.533 (0.309-0.921)0.024 1.165 (0.584-2.322)0.665 0.467 (0.268-0.815)0.0071.232 (0.581-2.610)0.586
Age (< 53.50 vs ≥ 53.50)0.978 (0.550-1.737)0.939 1.276 (0.721-2.256)0.403
Sex (Male vs Female)1.288 (0.689-2.410)0.428 1.275 (0.682-2.385)0.447
TNM stage (Ⅲ vs Ⅳ)1.586 (0.820-3.067)0.170 2.044 (1.031-4.052)0.0412.313 (1.007-5.317)0.048
Sarcopenia (Yes vs No)2.896 (1.670-5.021)< 0.0013.569 (1.808-7.045)< 0.0013.021 (1.737-5.253)< 0.0014.036 (1.959-8.316)< 0.001
Myosteatosis (Yes vs No)2.662 (1.357-5.225)0.0043.172 (1.471-6.839)0.003 2.104 (1.118-3.962)0.0212.624 (1.256-5.483)0.010
ALT: Alanine transaminase; AST: Aspartate aminotransferase; γ-GGT: γ-glutamyl transferase; ALP: Alkaline phosphatase; TBIL: Total bilirubin; DBIL: Direct bilirubin; IDBIL: Indirect bilirubin; TP: Total protein; ALB: Albumin; GLOB: Globulin; PALB: Pre-albumin; Urea: Urea nitrogen; CREA: Creatinine; UA: Uric acid; LDH: Lactate dehydrogenase; WBC: White blood cell count; NEU: Neutrophil count; Lym: Lymphocyte count; Mono: Monocyte count; Eosi: Eosinophil count; Baso: Basophil count; Hb: Hemoglobin; RBC: Red blood cell count; Plt: Platelet count; Fbg: Fibrinogen; DDi: D-dimer; PFS: Progression-free survival; OS: Overall survival.