Recombinant adeno-associated virus 8-mediated inhibition of microRNA let-7a ameliorates sclerosing cholangitis in a clinically relevant mouse model

Figure 7 Let-7a-5p inhibition mediated by adeno-associated virus 8 ameliorates local pro-inflammatary cytokines produced. The levels of Il6, Tnfa, and Ccl₂ in the liver of mice from each group after 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine (DDC) feeding for 2 or 6 wk were evaluted by qPCR. A-C: The relative levels of Il6, Tnfa, and Ccl₂ after 2 wk DDC feeding; D-F: The relative levels of Il6, Tnfa, and Ccl₂ after 6 wk DDC feeding. DDC: 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine; SCR: Scramble control. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001.