Recombinant adeno-associated virus 8-mediated inhibition of microRNA let-7a ameliorates sclerosing cholangitis in a clinically relevant mouse model

Figure 3 Recombinant adeno-associated virus 8 mediated anti-let-7a-5p protects from 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-induced hepato-biliary damages. A: The ratio of Liver weight to body weight; B-E: Serum levels of aspartate aminotransferase, total bilirubin, alanine aminotransferase, and alkaline phosphatase in the normal control, scramble control, and anti-let-7a sponge (anti-let-7a-5p) mice for 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine feeding at the indicated time (2 wk and 6 wk). DDC: 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine; SCR: Scramble control; AST: Aspartate aminotransferase; BILT: Total bilirubin; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; TBA: Total bile acid. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001.