N6-methyladenosine-modified long non-coding RNA KIF9-AS1 promotes stemness and sorafenib resistance in hepatocellular carcinoma by upregulating SHOX2 expression

doi:10.3748/wjg.v30.i48.5174

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2024; 30(48): 5174-5190
Published online Dec 28, 2024. doi: 10.3748/wjg.v30.i48.5174

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Figure 8 The mechanism by which the m6A-modified long noncoding RNA KIF9-AS1 promotes stemness and sorafenib resistance in hepatocellular carcinoma through ubiquitin-specific peptidase 1-mediated deubiquitination of short stature homeobox 2. HCC: Hepatocellular carcinoma; USP1: Ubiquitin-specific peptidase 1; SHOX2: Short-stature homeobox 2; METTL3: Methyltransferase-like 3; IGF2BP1: Insulin-like growth factor 2 mRNA binding protein 1; m6A: N6-methyladenosine; Ub: Ubiquitin.

Citation: Yu Y, Lu XH, Mu JS, Meng JY, Sun JS, Chen HX, Yan Y, Meng K. N6-methyladenosine-modified long non-coding RNA KIF9-AS1 promotes stemness and sorafenib resistance in hepatocellular carcinoma by upregulating SHOX2 expression. World J Gastroenterol 2024; 30(48): 5174-5190
URL: https://www.wjgnet.com/1007-9327/full/v30/i48/5174.htm
DOI: https://dx.doi.org/10.3748/wjg.v30.i48.5174