Helicobacter pylori infection is associated with the risk and phenotypes of cholelithiasis: A multi-center study and meta-analysis

Table 3 The results of phenotype analysis and parameters comparison

	H. pylori+	H. pylori-	P value
Phenotype
Hepatolithiasis (n)	21	53	0.546
Cholecystolithiasis (n)	942	2782
Parameters
Total bilirubin (μmol/L)	12.5 ± 5.2	13.2± 5.2	< 0.001
Direct bilirubin (μmol/L)	3.6 ± 1.6	3.9 ± 1.6	< 0.001
Total bile acid (μmol/L)	3.8± 5.1	3.6 ± 4.3	0.055
Total cholesterol (mmol/L)	4.84 ± 0.90	4.77 ± 0.86	< 0.001
Triglyceride (mmol/L)	1.26 ± 0.94	1.27 ± 1.00	0.489
HDL-cholesterol (mmol/L)	1.41 ± 0.29	1.41 ± 0.29	0.994
LDL-cholesterol (mmol/L)	2.83 ± 0.76	2.76 ± 0.73	< 0.001

H. pylori: Helicobacter pylori; H. pylori+: Helicobacter pylori-positive; H. pylori-: Helicobacter pylori-negative; LDL: Low-density lipoprotein; HDL: High-density lipoprotein.