Multi-clustering study on the association between human leukocyte antigen-DP-DQ and hepatitis B virus-related hepatocellular carcinoma and cirrhosis in Viet Nam

Figure 3 Linkage disequilibrium pairwise map. The physical distance separating these single nucleotide polymorphisms (SNPs) was 29,816 kb, and the D value ranges from 0.07 to 0.42. The disequilibrium is strong when D' ≥ 0.80, moderate when D' is around 0.50, and weak when D' is 0. Significantly, the closed linkage between rs3077 and rs9277535 is due to the distance of 21kb. We found decreasment of D' from the healthy control (D’ = 0.50, P < 0.05) to the hepatic diseases group (D' < 0.3, P < 0.05), which means from the moderate to the weak disequilibrium. The variant rs2856718 showed a moderate linkage disequilibrium with rs3077 (D’ from 0.27 to 0.34) but very weak with rs9277535 (D’ from 0.07 to 0.20). This might predict the independence of this SNP to disease status except when a specific genotype of rs3077 influenced it.