Lipocalin-2 and intestinal diseases

Figure 2 Regulation of lipocalin-2 biosynthesis (schematic diagram). The factors influencing lipocalin 2 expression alterations across various models were summarized. TNFα: Tumor necrosis factor-alpha; LPS: Lipopolysaccharide; TRAD: Protein TraD; TRAF: Tumor necrosis factor receptor-associated factors; IAP: Inhibitor of apoptosis proteins; RIPK1: Receptor-interacting protein kinase 1; CARD9: Caspase-recruitment domain 9; IKK: IκB kinase; NLPR3: NLR-family pyrin domain-containing protein 3; IKB: Inhibitor of kB; NFKB: Nuclear factor kappa light chain enhancer of activated B; JAK: Janus kinase; SOC3: Suppressor of cytokine signaling 3; STAT1/3: Signal transducer and activator of transcription 1/3; S1P: Sphingosine-1-phosphate; S1PR: Sphingosine-1-phosphate receptor; H3K27m³: Histone H3 lysine 27 trimethylation; KDM6A: Lysine-specific demethylase 6A; LCN2: Lipocalin-2.