Multi-clustering study on the association between human leukocyte antigen-DP-DQ and hepatitis B virus-related hepatocellular carcinoma and cirrhosis in Viet Nam

Table 6 The risk ratio results of haplotype rs2856718-rs30277-rs9277535 following the preclinical factors

Preclinical factors	Groups	Female	Male	All
Total bilirubin (µmol/L); Normal range: < 17 µmol/L	Hepatitis	AG/GG/GG
		RR = 0.72 (0.49; 1.06)
		Cutpoint = 7.08 µmol/L
		Nupper/Nlower = 10/6
		Pfisher = 0.017, Pyates = 0.027, Puncor = 0.011
	HCC		AG/GG/GG
			RR = 1.45 (1.05; 1.99)
			Cutpoint = 43.6 µmol/L
			Nupper/Nlower = 25/19
			Pfisher = 0.02, Pyates= 0.03, Puncor = 0.02
AFP (IU/mL); Normal range: < 5.8 IU/mL	Hepatitis	AA/GG/GG
		RR = 0.44 (0.20; 0.99)
		Cutpoint = 33.11 U/mL
		Nupper/Nlower = 4/7
		Pfisher = 0.008, Pyates = 0.008, Puncor = 0.002
ALB (g/L); Normal range: 35-50 g/L	HCC			GG/AG/AG
				RR = 2.20 (1.24; 3.92)
				Cutpoint = 43.6 g/L
				Nupper/Nlower = 8/10
				Pfisher = 0.016, Pyates = 0.018, Puncor = 0.008
Direct bilirubin (µmol/L); Normal range: < 4.3 µmol/L	HCC			GG/AG/GG
				RR = 1.57 (1.09; 2.25)
				Cutpoint = 5.13 µmol/L
				Nupper/Nlower = 11/5
				Pfisher = 0.034, Pyates = 0.046, Puncor = 0.026
Tumor size (cm)	HCC			GG/AA/AG	AA/GG/AG
				RR = 2.2 (1.94; 2.56)	RR = 2.25 (1.96; 2.59)
				Cutpoint = 5 cm	Cutpoint = 5 cm
				Nupper/NloweRR = 5/0	Nupper/NloweRR = 3/0
				Pfisher = 0.009, Pyates = 0.02, Puncor = 0.006	Pfisher = 0.046, Pyates = 0.092, Puncor = 0.028
ALT (U/L); Normal range: < 40 U/L at 37 oC	HCC			GG/AG/AG
				RR = 0.74 (0.49; 1.13)
				Cutpoint = 28.8 U/L
				Nupper/Nlower = 10/8
				Pfisher = 0.048, Pyates = 0.068, Puncor = 0.038
AST (U/L); Normal range: < 37 U/L at 37 oC	HCC		GG/GG/GG	GG/GG/GG
			RR = 0.52 (0.25; 1.10)	RR = 0.53 (0.27; 1.06)
			Cutpoint = 58.9 U/L	Cutpoint = 58.9 U/L
			Nupper/Nlower = 6/26	Nupper/Nlower = 7/30
			Pfisher = 0.034, Pyates = 0.043, Puncor = 0.028	Pfisher = 0.029, Pyates = 0.036, Puncor = 0.024
Age (years old)	Hepatitis	GG/AG/AG
		RR = 0.63 (0.31; 1.28)
		Cutpoint = 31 years old
		Nupper/Nlower = 3/2
		Pfisher = 0.013, Pyates = 0.0086, Puncor = 0.0004
	Cirrhosis			AA/AG/AG
				RR = 0.38 (0.11; 1.31)
				Cutpoint = 52 years old
				Nupper/Nlower = 2/7
				Pfisher = 0.023, Pyates = 0.038, Puncor = 0.018
	HCC			GG/GG/GG
				RR = 1.63 (0.98; 2.71)
				Cutpoint = 63 years old
				Nupper/Nlower = 13/24
				Pfisher = 0.045, Pyates = 0.055, Puncor = 0.035
Gender (Female, male)	Hepatitis			AG/AG/GG
				RR = 0.76 (0.56; 1.02)
				Cutpoint = Male
				Nmale/Nfemale = 18/12
				Pfisher = 0.03, Pyates = 0.01, Puncor = 0.007
	HCC			AA/GG/GG		AG/AG/GG
				RR = 0.74 (0.567; 0.96)		RR = 1.20 (1.13; 1.27)
				Cutpoint = Male		Cutpoint = Male
				Nmale/Nfemale = 12/11		Nmale/Nfemale = 18/0
				Pfisher = 0.001, Pyates = 0.001, Puncor = 0.0005		Pfisher = 0.04, Pyates = 0.06, Puncor = 0.02
GGT (U/L); Male: 11-50 U/L at 37 oC; Female: 7-32 U/L at 37 oC	Cirrhosis			AG/GG/GG
				RR = 1.71 (1.09; 2.70)
				Cutpoint = 181.97 U/L
				Nupper/Nlower = 15/21
				Pfisher = 0.02, Pyates = 0.024, Puncor = 0.014

HCC: Hepatocellular carcinoma; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALB: Albumin; GGT: Gamma glutamyl transferase.