Multi-clustering study on the association between human leukocyte antigen-DP-DQ and hepatitis B virus-related hepatocellular carcinoma and cirrhosis in Viet Nam

Table 5 Risk ratio of haplotype rs2856718-rs30277-rs9277535

Haplotype: Rs2856718, rs30277, rs9277535		A/G_A/G_A	A/G_A/G_A/	A/G_A/G_G	A/G_A_A	A/G_A_A/G	A/G_A_G	A/G_G_A	A/G_G_A/G	A/G_G_G	A_A/G_A	A_A/G_A/G	A_A/G_G	A_A_A	A_A_A/G	A_A_G	A_G_A	A_G_A/G	A_G_G	G_A/G_A	G_A/G_A/G	G_A/G_G	G_A_A	G_A_A/G	G_A_G	G_G_A	G_G_A/G	G_G_G
Hepatitis	N	2	51	30	NA	4	3	NA	35	83	1	17	11	1	2	1	NA	12	45	1	37	46	4	11	3	NA	18	53
	%	0.4	10.8	6.4	NA	0.8	0.6	NA	7.4	17.6	0.2	3.6	2.3	0.2	0.4	0.2	NA	2.5	9.6	0.2	7.9	9.8	0.8	2.3	0.6	NA	3.8	11.3
	Pfisher	1.15 × 10-01	3.89 × 10-01	3.24 ×10-01	1.53 × 10-02	2.96 × 10-01	3.78 × 10-01	1.52 × 10-01	2.85 × 10-01	1.95 × 10-01	5.00 × 10-01	1.54 × 10-01	4.27 × 10-01	2.12 × 10-01	5.00 × 10-01	5.00 × 10-01	2.68 × 10-01	2.83 × 10-01	3.86 × 10-01	8.36 × 10-02	3.38 × 10-01	1.47 × 10-02	1.59 × 10-01	4.24 × 10-01	5.00 × 10-01	5.00 × 10-01	3.19 × 10-01	3.60 × 10-01
	Pyates	1.27 × 10-01	4.18 ×10-01	3.18 × 10-01	2.62 × 10-02	2.97 × 10-01	3.71 × 10-01	1.58 × 10-01	3.30 × 10-01	2.05 × 10-01	5.00 × 10-01	1.88 × 10-01	4.69 × 10-01	2.77 × 10-01	5.00 × 10-01	5.00 × 10-01	3.67 × 10-01	3.65 × 10-01	3.97 × 10-01	1.06 × 10-01	3.64 × 10-01	1.78 × 10-02	1.91 × 10-01	5.00 × 10-01	5.00 × 10-01	5.00 × 10-01	3.73 × 10-01	3.76 × 10-01
	Puncor	7.49 × 10-02	3.82 × 10-01	2.79 × 10-01	1.11 × 10-02	2.11 × 10-01	2.60 × 10-01	6.40 × 10-02	2.90 × 10-01	1.83 × 10-01	3.15 × 10-01	1.45 × 10-01	3.96 ×10-01	1.55 × 10-01	4.34 × 10-01	3.47 × 10-01	1.41 × 10-01	2.94 × 10-01	3.61 × 10-01	5.56 × 10-02	3.25 × 10-01	1.35 × 10-02	1.30 × 10-01	4.40 × 10-01	4.79 × 10-01	2.24 × 10-01	3.15 × 10-01	3.42 × 10-01
	RR	0.45	1.04	0.92	NA	0.73	0.74	NA	1.08	1.09	0.68	1.23	0.94	0.45	0.91	1.37	NA	1.13	0.96	0.3	0.94	1.31	0.64	1.04	1.02	NA	1.1	0.95
	Lower	0.13	0.82	0.68	NA	0.31	0.28	NA	0.83	0.91	0.12	0.86	0.58	0.08	0.29	0.34	NA	0.73	0.75	0.05	0.72	1.05	0.27	0.65	0.42	NA	0.76	0.76
	Upper	1.61	1.3	1.24	NA	1.69	1.96	NA	1.41	1.31	3.73	1.77	1.52	2.72	2.83	5.48	NA	1.76	1.22	1.92	1.23	1.64	1.51	1.66	2.51	NA	1.58	1.2
HCC	N	2	23	18	1	3	2	2	20	48	NA	5	NA	NA	3	1	NA	5	31	2	18	16	1	3	1	1	8	37
	%	0.8	9.2	7.2	0.4	1.2	0.8	0.8	8	19.1	NA	2	NA	NA	1.2	0.4	NA	2	12.4	0.8	7.2	6.4	0.4	1.2	0.4	0.4	3.2	14.7
	Pfisher	5.00 × 10-01	2.46 × 10-01	4.45 × 10-01	5.00 × 10-01	5.00 × 10-01	5.00 × 10-01	8.65 × 10-02	2.44 × 10-01	1.08 × 10-01	5.00 × 10-01	2.04 × 10-01	6.15 × 10-04	3.02 × 10-01	4.62 × 10-02	1.76 × 10-01	5.00 × 10-01	5.00 × 10-01	7.96 × 10-02	3.45 × 10-01	2.63 × 10-01	2.53 × 10-01	1.10 × 10-01	1.70 × 10-01	5.00 × 10-01	9.75 × 10-02	5.00 × 10-01	5.09 × 10-02
	Pyates	5.00 × 10-01	2.58 × 10-01	4.84 × 10-01	4.15 × 10-01	5.00 × 10-01	5.00 × 10-01	1.81 × 10-01	2.76 × 10-01	1.14 × 10-01	3.62 × 10-01	2.14 × 10-01	4.75 × 10-03	2.44 × 10-01	8.48 × 10-02	4.22 × 10-01	5.00 × 10-01	4.71 × 10-01	9.65 × 10-02	5.00 × 10-01	2.73 × 10-01	2.44 × 10-01	1.32 × 10-01	1.53 × 10-01	4.79 × 10-01	2.21 × 10-01	4.58 × 10-01	6.16 × 10-02
	Puncor	4.02 × 10-01	2.22 × 10-01	4.29 × 10-01	2.62 × 10-01	4.81 × 10-01	4.56 × 10-01	6.16 × 10-02	2.32 × 10-01	9.65 × 10-02	1.62 × 10-01	1.58 × 10-01	2.40 × 10-03	1.13 × 10-01	2.94 × 10-02	1.38 × 10-01	2.43 × 10-01	3.78 × 10-01	7.79 × 10-02	4.18 × 10-01	2.32 × 10-01	2.05 × 10-01	7.68 × 10-02	1.04 × 10-01	3.08 × 10-01	2.11 × 10-02	3.83 × 10-01	4.94 × 10-02
	RR	0.85	0.86	1.04	0.57	1.03	0.93	2.58	1.17	1.21	NA	0.67	NA	NA	2.58	2.57	NA	0.88	1.28	1.14	0.85	0.83	0.3	0.52	0.64	5.14	0.91	1.3
	Lower	0.24	0.58	0.68	0.09	0.37	0.26	0.96	0.78	0.91	NA	0.29	NA	NA	1.15	0.64	NA	0.39	0.92	0.33	0.55	0.52	0.04	0.18	0.1	4.6	0.48	0.96
	Upper	3.04	1.27	1.6	3.62	2.84	3.28	6.91	1.74	1.59	NA	1.52	NA	NA	5.79	10.32	NA	1.97	1.77	3.89	1.32	1.31	2.01	1.54	4.01	5.75	1.72	1.76
Cirrhosis	N	1	21	19	1	2	1	1	17	36	2	9	9	1	NA	NA	1	6	24	2	22	20	4	6	1	NA	12	32
	%	0.4	8.4	7.6	0.4	0.8	0.4	0.4	6.8	14.4	0.8	3.6	3.6	0.4	NA	NA	0.4	2.4	9.6	0.8	8.8	8	1.6	2.4	0.4	NA	4.8	12.8
	Pfisher	2.40 × 10-01	1.26 × 10-01	3.38 × 10-01	5.00 × 10-01	3.74 × 10-01	3.51 × 10-01	2.89 × 10-01	5.00 × 10-01	1.96 × 10-01	8.59 × 10-02	2.66 × 10-01	1.27 × 10-01	5.00 × 10-01	3.02 × 10-01	5.00 × 10-01	1.75 × 10-01	4.07 × 10-01	4.53 × 10-01	3.45 × 10-01	3.99 × 10-01	3.95 × 10-01	3.78 × 10-01	4.07 × 10-01	5.00 × 10-01	5.00 × 10-01	1.24 × 10-01	2.92 × 10-01
	Pyates	2.71 × 10-01	1.39 × 10-01	3.68 ×10-01	4.17 ×10-01	3.93 × 10-01	3.13 × 10-01	5.00 ×10-01	5.00 × 10-01	1.97 × 10-01	1.80 × 10-01	3.21 × 10-01	1.51 × 10-01	5.00 × 10-01	2.46 × 10-01	5.00 × 10-01	4.21 × 10-01	5.00 × 10-01	4.66 × 10-01	5.00 × 10-01	4.28 × 10-01	4.51 × 10-01	4.51 × 10-01	5.00 × 10-01	4.81 × 10-01	5.00 × 10-01	1.45 × 10-01	3.17 × 10-01
	Puncor	1.65 × 10-01	1.15 × 10-01	3.17 × 10-01	2.63 × 10-01	2.74 × 10-01	1.92 × 10-01	3.89 × 10-01	4.68 × 10-01	1.71 × 10-01	6.08 × 10-02	2.50 × 10-01	1.04 × 10-01	4.32 ×10-01	1.14 × 10-01	2.44 × 10-01	1.37 × 10-01	4.31 × 10-01	4.19 × 10-01	4.16 × 10-01	3.78 × 10-01	3.99 × 10-01	3.33 × 10-01	4.31 × 10-01	3.10 × 10-01	3.12 × 10-01	1.06 × 10-01	2.80 × 10-01
	RR	0.43	0.78	1.11	0.57	0.68	0.47	1.29	0.98	0.86	2.59	1.23	1.46	0.86	NA	NA	2.58	1.07	0.96	1.15	1.06	1.06	1.21	1.07	0.64	NA	1.39	1.1
	Lower	0.07	0.52	0.73	0.09	0.19	0.07	0.24	0.63	0.62	0.96	0.69	0.83	0.14	NA	NA	0.64	0.52	0.66	0.34	0.72	0.7	0.51	0.52	0.1	NA	0.85	0.79
	Upper	2.8	1.18	1.68	3.63	2.5	3.03	7.06	1.53	1.18	6.94	2.2	2.58	5.15	NA	NA	10.36	2.19	1.4	3.91	1.57	1.59	2.88	2.19	4.03	NA	2.29	1.54
Healthy control	N	7	40	22	7	6	5	1	17	44	1	7	12	4	1	NA	1	6	28	4	30	16	8	9	3	NA	7	29
	%	2.2	12.7	7	2.2	1.9	1.6	0.3	5.4	14	0.3	2.2	3.8	1.3	0.3	NA	0.3	1.9	8.9	1.3	9.5	5.1	2.5	2.9	1	NA	2.2	9.2
	Pfisher	6.13 × 10-03	7.00 × 10-02	5.00 × 10-01	5.62 × 10-04	1.11 × 10-01	7.52 × 10-02	5.00 × 10-01	1.26 × 10-01	9.50 × 10-02	5.00 × 10-01	2.24 × 10-01	4.77 × 10-02	1.73 × 10-02	5.00 ×10-01	5.00 × 10-01	2.15 × 10-01	4.14 × 10-01	2.58 × 10-01	1.17 × 10-01	2.05 × 10-01	2.55 × 10-02	2.15 × 10-02	1.94 × 10-01	2.07 × 10-01	5.00 × 10-01	1.08 × 10-01	6.52 × 10-02
	Pyates	8.12 × 10-03	8.59 × 10-02	5.00 ×10-01	4.14 × 10-04	1.35 × 10-01	1.01 × 10-01	5.00 × 10-01	1.37 × 10-01	1.05 × 10-01	5.00 × 10-01	2.45 × 10-01	6.34 × 10-02	2.66 × 10-02	5.00 × 10-01	5.00 × 10-01	4.93 × 10-01	3.97 × 10-01	2.70 × 10-01	1.56 × 10-01	2.18 × 10-01	3.36 × 10-02	2.90 × 10-02	2.70 × 10-01	3.27 × 10-01	5.00 × 10-01	1.07 × 10-01	6.65 × 10-02
	Puncor	3.06 × 10-03	7.05 × 10-02	4.78 × 10-01	9.49 × 10-05	7.98 × 10-02	5.20 × 10-02	4.90 × 10-01	1.11 × 10-01	9.04 × 10-02	4.90 × 10-01	1.89 × 10-01	4.13 × 10-02	7.99 × 10-03	3.28 × 10-01	2.10 × 10-01	2.00 × 10-01	3.16 × 10-01	2.35 × 10-01	8.10 × 10-02	1.85 × 10-01	2.55 × 10-02	1.46 × 10-02	2.03 × 10-01	1.95 × 10-01	2.85 × 10-01	7.83 × 10-02	5.44 × 10-02
	RR	0.55	0.92	1.00	0.29	0.79	0.72	0.99	1.08	1.06	0.99	1.08	0.82	0.44	1.10	1.32	0.66	1.05	1.04	0.73	0.95	1.12	0.70	0.91	0.83	1.32	1.12	1.08
	Lower	0.28	0.82	0.88	0.09	0.52	0.42	0.56	0.97	0.98	0.56	0.93	0.63	0.14	0.77	1.28	0.17	0.87	0.94	0.41	0.84	1.02	0.45	0.71	0.48	1.28	0.99	0.99
	Upper	1.07	1.04	1.13	0.99	1.20	1.24	1.75	1.20	1.14	1.75	1.26	1.08	1.37	1.58	1.37	2.65	1.27	1.14	1.32	1.07	1.23	1.09	1.17	1.42	1.37	1.28	1.18

HCC: Hepatocellular carcinoma; RR: Risk ratio; NA: Not available.