Multi-clustering study on the association between human leukocyte antigen-DP-DQ and hepatitis B virus-related hepatocellular carcinoma and cirrhosis in Viet Nam

doi:10.3748/wjg.v30.i46.4880

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Dec 14, 2024 (publication date) through Jan 20, 2025

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Dec 14, 2024; 30(46): 4880-4903
Published online Dec 14, 2024. doi: 10.3748/wjg.v30.i46.4880

Table 2 Correlation of human leukocyte antigen-DP and human leukocyte antigen-DQ polymorphisms with the risk of chronic active hepatitis B, n (%)

SNPs	Healthy control	HBV carrier			Healthy control vs CHB		Healthy control vs HBV carrier
SNPs	Healthy control	CHB	HBV-related LC	HBV-related HCC	OR (95%CI)	P value	OR (95%CI)	P value
rs2856718
GG	106 (33.7)	173 (36.7)	100 (40.0)	87 (34.7)	1		1
AG	149 (47.3)	208 (44.2)	97 (38.8)	119 (47.4)	0.855 (0.621-1.179)	0.3392	0.838 (0.630-1.115)	0.2253
AA	60 (19.0)	90 (19.1)	53 (21.2)	45 (17.9)	0.919 (0.612-1.380)	0.6840	0.923 (0.642-1.326)	0.6631
AA + AG	209 (66.3)	298 (63.3)	150 (60.0)	164 (65.3)	0.874 (0.648-1.179)	0.3767	0.862 (0.660-1.127)	0.2774
G allele	361 (57.3)	554 (58.8)	297 (59.4)	293 (58.4)	1		1
A allele	269 (42.7)	384 (41.2)	203 (40.6)	209 (41.6)	0.930 (0.758-1.141)	0.4882	0.939 (0.782-1.126)	0.4937
rs3077
GG	133 (42.2)	246 (52.2)	128 (51.2)	152 (60.5)	1		1
AG	139 (44.1)	196 (41.6)	107 (42.8)	84 (33.5	0.762 (0.563-1.032)	0.0702	0.704 (0.537-0.924)	0.0113
AA	43 (13.7)	29 (6.2)	15 (6.0)	15 (6.0)	0.365 (0.218-0.611)	0.0001	0.347 (0.224-0.537)	< 0.0001
AA + AG	182 (57.8)	225 (47.8)	122 (48.8)	99 (39.5)	0.668 (0.501-0.891)	0.0060	0.620 (0.479-0.801)	0.0003
G allele	405 (64.3)	688 (73.0)	364 (72.5)	388 (77.3)	1		1
A allele	225 (35.7)	254 (27.0)	138 (27.5)	114 (22.7)	0.665 (0.535-0.826)	0.0002	0.632 (0.521-0.765)	< 0.0001
rs9277535
GG	159 (50.5)	275 (58.4)	142 (56.8)	154 (61.4)	1		1
AG	123 (39.0)	187 (39.7)	95 (38.0)	88 (35.0)	0.879 (0.651-1.186)	0.3993	0.838 (0.640-1.097)	0.1972
AA	33 (10.5)	9 (1.9)	13 (5.2)	9 (3.6)	0.158 (0.074-0.338)	< 0.0001	0.262 (0.155-0.440)	< 0.0001
AA + AG	156 (49.5)	196 (41.6)	108 (43.2)	97 (38.6)	0.726 (0.545-0.968)	0.0290	0.716 (0.555-0.924)	0.0102
G allele	441 (70.0)	737 (78.1)	379 (75.8)	396 (78.9)	1		1
A allele	189 (30.0)	205 (21.9)	121 (24.2)	106 (21.1)	0.649 (0.516-0.817)	0.0002	0.667 (0.545-0.815)	0.0001

CHB: Chronic Hepatitis B virus; HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma; LC: Liver cirrhosis.

Citation: Nguyen TT, Ho TC, Bui HTT, Tran VK, Nguyen TT. Multi-clustering study on the association between human leukocyte antigen-DP-DQ and hepatitis B virus-related hepatocellular carcinoma and cirrhosis in Viet Nam. World J Gastroenterol 2024; 30(46): 4880-4903
URL: https://www.wjgnet.com/1007-9327/full/v30/i46/4880.htm
DOI: https://dx.doi.org/10.3748/wjg.v30.i46.4880