Quantitative proteomics analysis reveals the pathogenesis of obstructed defecation syndrome caused by abnormal expression of dystrophin

Figure 1 Analysis of differential proteins by isobaric tag for relative and absolute quantification-based quantitative proteomics. A: Heatmap of all differential proteins in the pathological pathway of dilated cardiomyopathy; B: Volcano plot of differentially expressed proteins; C: Cluster of Orthologous Groups of proteins classification annotation results of differentially expressed proteins; D: Gene Ontology classification statistical plot of differentially expressed proteins; E: Kyoto Encyclopedia of Genes and Genomes (KEGG) classification annotation results of differentially expressed proteins; F: Subcellular localization of differentially expressed proteins; G: KEGG enrichment analysis of differentially expressed proteins. The top 10 most significantly enriched categories are shown in the bubble chart [-log10 (adjusted P value)]. The circle color indicates the enrichment P value, and the circle size indicates the number of differentially expressed proteins in the functional pathway; H: Protein interaction network of significant enrichment pathways associated with muscle contraction disorders. Red indicates up-regulated proteins expressed by the control group relative to the obstructed defecation syndrome group. Blue indicates down-regulated proteins. COG: Cluster of Orthologous Groups; GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes.