Validation of prognostic scores for predicting acute liver failure and in-hospital death in patients with dengue-induced severe hepatitis

Table 3 Univariate regression analysis of factors associated with severe adverse outcomes from dengue-induced severe hepatitis

Parameter	Acute liver failure			In-hospital mortality
	OR	95%CI	P value	OR	95%CI	P value
Clinical parameter
Presence of DSS	34.62	11.71-102.33	< 0.001	28.05	7.21-109.18	< 0.001
Laboratory parameters
INR	72.27	10.98-475.89	< 0.001	5.83	2.59-13.12	< 0.001
SGOT	1.00	1.00-1.00	< 0.001	1.00	1.00-1.00	< 0.001
SGPT	1.00	1.00-1.00	< 0.001	1.00	1.00-1.00	0.002
Albumin	0.11	0.04-0.31	< 0.001	0.15	0.05-0.44	< 0.001
Cr	2.08	1.31-3.31	0.002	1.52	1.00-2.31	0.051
Liver prognostic scores
MELD score	1.34	1.21-1.48	< 0.001	1.15	1.07–1.22	< 0.001
ALBI score	5.01	2.65-11.43	< 0.001	3.22	1.52-6.80	0.002
PALBI score	7.67	2.90-20.26	< 0.001	3.51	1.26-9.82	0.017
EZ-ALBI score	1.28	1.15-1.41	< 0.001	1.07	1.00-1.14	0.038

OR: Odds ratio; DSS: Dengue shock syndrome; INR: International normalized ratio; Cr: Creatinine; SGOT: Serum glutamate-oxaloacetate transaminase; SGPT: Serum glutamate-pyruvate transaminase; MELD: Model for end-stage liver disease; ALBI: Albumin-bilirubin; EZ-ALBI: Easy albumin-bilirubin; PALBI: Platelet-albumin-bilirubin.