Copyright
©The Author(s) 2024.
World J Gastroenterol. Nov 28, 2024; 30(44): 4725-4737
Published online Nov 28, 2024. doi: 10.3748/wjg.v30.i44.4725
Published online Nov 28, 2024. doi: 10.3748/wjg.v30.i44.4725
Characteristics | OR | 95%CI | P value |
Age (years) | 0.962 | (0.916-1.012) | 0.133 |
Gender | 1.692 | (0.588-4.870) | 0.329 |
Family history of HBV infection | 0.655 | (0.227-1.890) | 0.434 |
Characteristics at the initiation of peg-IFN-α | |||
HBsAg level, IU/mL | 1.000 | (1.000-1.000) | 0.398 |
HBsAb negative | 0.933 | (0.107-8.130) | 0.950 |
HBV DNA positive | 0.514 | (0.176-1.506) | 0.225 |
HBeAg positive | 1.448 | (0.302-6.934) | 0.643 |
Peg-IFN-α-2a | 1.624 | (0.558-4.730) | 0.374 |
Peg-IFN-α monotherapy | 0.588 | (0.224-1.546) | 0.282 |
Treatment time of peg-IFN-α (weeks) | 1.014 | (0.992-1.035) | 0.217 |
Total duration of peg-IFN-α (weeks) | 0.999 | (0.975-1.024) | 0.9570 |
Consolidation time < 12 weeks | 25.636 | (7.039-93.356) | < 0.001 |
Characteristics at the cessation of peg-IFN-α | |||
Without HBsAg seroconversion | 5.252 | (1.684-16.376) | 0.004 |
HBsAb, mIU/mL | 0.952 | (0.914-0.992) | 0.018 |
HBsAb < 35.3 mIU/mL | 9.705 | (2.098-44.883) | 0.004 |
HBsAb disappeared during the follow-up | 14.500 | (1.513-138.972) | 0.020 |
ALT level at baseline, IU/L | 1.011 | (1.001-1.021) | 0.127 |
FibroScan values at baseline (kPa) | 1.314 | (0.791-2.183) | 0.292 |
- Citation: Lu R, Zhang M, Liu ZH, Hao M, Tian Y, Li M, Wu FP, Wang WJ, Shi JJ, Zhang X, Jia XL, Jiang ZC, Li XM, Xu GH, Li YP, Dang SS. Recurrence and influencing factors of hepatitis B surface antigen seroclearance induced by peginterferon alpha-based regimens. World J Gastroenterol 2024; 30(44): 4725-4737
- URL: https://www.wjgnet.com/1007-9327/full/v30/i44/4725.htm
- DOI: https://dx.doi.org/10.3748/wjg.v30.i44.4725