Prognostic impact and reasons for variability by tumor location in gastric cancer

Table 3 Correlations between tumor location and clinicopathologic characteristics of gastric cancer patients

Characteristics	Tumor location
	Middle	Lower	Upper	Total	P value
Gender
Male	390	1285	826	40	< 0.001
Female	117	436	181	12
Age
< 60	228	692	248	23	< 0.001
≥ 60	279	1029	759	29
BMI
≤ 18	40	161	89	6	0.354
18-24	306	1107	645	32
≥ 24	161	453	273	14
Family history
No	320	1125	629	28	0.177
Yes	187	596	378	24
Smoking history
No	290	935	515	27	0.140
Yes	217	786	492	25
Drinking history
No	364	1178	682	37	0.409
Yes	143	543	325	15
Range of resection
Proximal	9	1	177	0	< 0.001
Distal	197	1515	5	2
Total	301	205	825	50
Differentiation
Well	2	15	5	0	< 0.001
Well-moderate	4	37	19	1
Moderate	101	363	300	7
Moderate-poor	193	693	397	17
Poor	207	613	286	27
Pathological type
Adenocarcinoma	460	1509	871	43	0.131
PMGC	20	111	72	3
MGC	27	101	64	6
Vascular tumor thrombus
No	281	923	501	15	0.001
Yes	226	798	506	37
Nerve invasion
No	266	1023	421	8	< 0.001
Yes	241	698	586	44
Maximum tumor diameter
< 5 cm	344	1129	505	4	< 0.001
≥ 5 cm	163	592	502	48
Tumor depth
T1	103	433	86	0	< 0.001
T2	80	265	100	2
T3	40	96	64	3
T4	284	927	757	47
Lymph node metastasis
N0	196	624	318	4	< 0.001
N1	101	331	186	4
N2	95	350	244	14
N3	115	416	259	30
pTNM
I	135	501	150	2	< 0.001
II	136	377	218	2
III	236	843	639	48
CEA
< 5	424	1369	753	32	< 0.001
≥ 5	83	352	254	20
CA19-9
< 37	423	1365	752	33	< 0.001
≥ 37	84	356	255	19
CA125
< 35	474	1635	950	42	< 0.001
≥ 35	33	86	57	10
AFP
< 10	484	1626	954	46	0.197
≥ 10	23	95	53	6
CA242
< 15	439	1448	812	36	0.001
≥ 15	68	273	195	16
CA72-4
< 6.9	432	1391	802	36	0.008
≥ 6.9	75	330	205	16

AFP: Alpha-fetoprotein; CEA: Carcinoembryonic antigen; CA: Carbohydrate antigen; BMI: Body mass index; pTNM: Pathological tumor-node-metastasis; PMGC: Peritoneal metastases of gastric cancer; MGC: Mucinous gastric carcinoma.