Plasma DNA methylation detection for early screening, diagnosis, and monitoring of esophageal adenocarcinoma and squamous cell carcinoma

Figure 1 SHOX2, RNF180, and EPO expression and methylation in normal esophageal tissue (n = 11) and esophageal cancer tissue (n = 181) samples from previously reported genome data. A, C, and E: Expression of SHOX2, RNF180, and EPO was up- or downregulated in esophageal cancer (EC) tissues (n = 181); B, D, and F: Promoter methylation levels of SHOX2, RNF180, and EPO in normal esophageal tissues (n = 11) and EC tissues (n = 181), as indicated by beta values ranging from 0 (unmethylated) to 1 (fully methylated). ^aP < 0.05. EC: Esophageal cancer.