Lenvatinib, sintilimab combined interventional treatment vs bevacizumab, sintilimab combined interventional treatment for intermediate-advanced unresectable hepatocellular carcinoma

doi:10.3748/wjg.v30.i43.4620

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Nov 21, 2024 (publication date) through Nov 1, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 21, 2024; 30(43): 4620-4635
Published online Nov 21, 2024. doi: 10.3748/wjg.v30.i43.4620

Table 2 Summary of the best responses, n (%)

Variable	RECIST 11			mRECIST
Variable	BeSiIT (n = 28)	LeSiIT (n = 50)	P value	BeSiIT (n = 28)	LeSiIT (n = 50)	P value
CR	0 (0.0)	0 (0.0)	-	8 (28.6)	4 (8.0)	0.016^a
PR	17 (60.7)	23 (46.0)	0.212	9 (32.1)	25 (50.0)	0.127
SD	5 (17.9)	7 (14.0)	0.651	5 (17.9)	5 (1.0)	0.319
PD	6 (21.4)	20 (40.0)	0.095	6 (21.4)	16 (32.0)	0.320
ORR	17 (60.7)	23 (46.0)	0.791	17 (60.7)	29 (58.0)	0.815
DCR	22 (78.6)	30 (60.0)	0.095	22 (78.6)	34 (68.0)	0.320

^aP value < 0.05, and it is statistically significant.

RECIST: Response Evaluation Criteria in Solid Tumors; mRECIST: Modified Response Evaluation Criteria in Solid Tumors; BeSiIT: Bevacizumab plus sintilimab plus interventional treatment; LeSiIT: Lenvatinib plus sintilimab plus interventional treatment; CR: Complete response; PR: Partial response; SD: Stable disease; PD: Progressive disease; ORR: Objective response rate; DCR: Disease control rate.

Citation: Han RY, Gan LJ, Lang MR, Ren SH, Liu DM, Li GT, Liu YY, Tian XD, Zhu KW, Sun LY, Chen L, Song TQ. Lenvatinib, sintilimab combined interventional treatment vs bevacizumab, sintilimab combined interventional treatment for intermediate-advanced unresectable hepatocellular carcinoma. World J Gastroenterol 2024; 30(43): 4620-4635
URL: https://www.wjgnet.com/1007-9327/full/v30/i43/4620.htm
DOI: https://dx.doi.org/10.3748/wjg.v30.i43.4620