Plasma DNA methylation detection for early screening, diagnosis, and monitoring of esophageal adenocarcinoma and squamous cell carcinoma

Table 1 Clinical characteristics of 210 patients with esophageal cancer

Clinicopathological data	n	SHOX2 methylation	Septin9 methylation	EPO methylation	RNF180 methylation	Combined methylation detection
Tumor pathology
Adenocarcinoma	33
Squamous cell carcinoma	177
P value		0.354	0.19	0.524	0.098	0.527
Gender
Male	122
Female	88
Male vs female		0.416	0.379	0.439	0.279	0.464
Age at diagnosis
≤ 60 years	73
> 60 years	137
Median age (years)	65.6
Mean age (years)	63.5
≤ 60 vs > 60 years		0.665	0.011	0.021	0.211	0.001
Tumor stage
I-II	19
III-IV	191
I-II vs III-IV		0.019	0.022	0.001	0.149	0.001
Follow-up
Follow-up available	23